-Sarcomatoid urothelial carcinoma (UCa) is a rare but aggressive variant of bladder cancer that can show diagnostic challenges even using ancillary techniques. Papillary urothelial carcinomas are dealt with in low-grade papillary urothelial carcinoma and high-grade papillary urothelial carcinoma. T1b - beyond muscularis mucosae - into submucosa. This page was last edited on 3 February 2017, at 20:44. Definition (radical cystectomy): tumour touching. Transitional cell carcinoma (TCC) of the renal pelvis, also called urothelial cell carcinoma (UCC) of the renal pelvis, is uncommon compared to renal cell carcinoma and can be challenging to identify on routine imaging when small.. Any of the following are evidence of invasion and exclude the diagnosis of inverted pattern Pathology Outlines. © Copyright PathologyOutlines.com, Inc. Click, High grade papillary urothelial carcinoma[title], Papillary nephrogenic adenoma / metaplasia, A neoplasm with urothelium lining papillary fronds, a predominant disorderly pattern and moderate to marked architectural and cytologic atypia, May invade adjacent structures or regional lymph nodes, Late dissemination to liver, lung, marrow, High rate (15-40%) of progression to invasive disease. The differential diagnosis includes (1) primary adenocarcinoma of the bladder, (2) adenocarcinoma from another organ (direct extension or metastasis), (3) urothelial Other urothelial neoplasias - esp. CK20 negative in over 50% of cases with metastases. We welcome suggestions or questions about using the website. Urothelial carcinoma (classic or recognizable variant). Urothelial carcinoma (classic or recognizable variant). The term Urothelial is preferred over Transitional as is is more specific and includes neoplasms with non-transitional differentiation arising in urothelium High grade and severe dysplasia as well as some moderate dysplasia are included in carcinoma in situ "Overstaging of transitional cell carcinoma: clinical significance of lamina propria fat within the urinary bladder.". Sarcomatoid differentiation - typically (undifferentiated) spindle cells. Pathology and Cox R, Epstein JI. Pathology of the ureter - overview Kidney stones. Distinguishing CIS and dysplasia from reactive atypia is often difficult on the basis of histological features alone. Urothelial neoplasms with squamous morphology raise the differential diagnosis between pure primary squamous cell carcinoma, urothelial carcinoma with squamous differentiation and secondary involvement by squamous cell carcinoma, for example, from … This article deals with flat invasive urothelial carcinoma. Lack of maturation to surface (important). Ta •All T1 treated as high-risk (EAU guidelines) Muscle invasive TCC Treatment options Radical therapy with/without neoadjuvant chemoRx •Radical radiotherapy •Radical cystectomy By Bahram Robert Oliai, M.D. World Health Organization Classification of Tumors. However, we cannot answer medical or research questions or give advice. 3.2 Risk factors Various environmental risk factors contribute to UTUC development [18, 19]. Webpathology.com: A Collection of Surgical Pathology Images Urothelial Carcinoma-in-situ "[Plasmacytoid urothelial carcinoma of the urinary bladder: a clinicopathologic study of 16 cases].". Sarcomatoid differentiation - typically (undifferentiated) spindle cells. Webpathology.com: A Collection of Surgical Pathology Images Urothelial Carcinoma-in-situ Higado y vesícula biliar virus rsv Cancer biliar imagenes Cancer biliar imagenes Cáncer vía biliar, Quiero Vivir simptome cancer osos picioare Cancerul de san carte hpv cancer no homem, papillary urothelial carcinoma pathology Related articles include: Urothelial carcinoma, also urothelial cell carcinoma, is a malignancy that arises from the urothelium. Visual survey of surgical pathology with 11065 high-quality images of benign and malignant neoplasms & related entities. Am J Surg Pathol 36 (7): 1081-6. doi : 10.1097/PAS.0b013e318253d6e0 . Focused Variants of Urothelial Carcinoma with stained slides of pathology… in Lynch syndrome - see urothelium. In approximately 15% of cases it is pT0 (no primary tumour identified). Currently, there is no widely used single marker or panel of markers to confirm urothelial … Invasion vs. in situ: USCAP abstract 901; 2013] 78% urothelial carcinoma cases +ve across all grades (compared with 56% +ve for uroplakin III) Specific when compared with various tissues, incl. Zhonghua Bing Li Xue Za Zhi 42 (7): 433-7. Papillary urothelial carcinoma is a form of bladder cancer. prostate and renal carcinoma The Christie NHS Foundation Trust NIR fluorescence dye ICG conjugated to Variant (divergent) histologic differentiation in urothelial carcinoma is under-recognized in community practice: Impact of mandatory central pathology review at a large referral hospital. Although most of us are familiar with the features, behavior and treatment of the “usual” type urothelial (so-called transitional cell)carcinoma, what do we do when the pathology report comes back with an unexpected and unusual diagnosis? Review – Urothelial Cancer Grading of Urothelial Carcinoma and The New “World Health Organisation Classification of Tumours of the Urinary System and Male Genital Organs 2016” Eva M. Compe´rata,*, Maximilian Burgerb, Paolo Gonteroc, A. Hugh Mostafidd, Joan Paloue, Cytokeratin 20 (CK20), p53, and Ki-67 are related either to neopla … Bladder, ureter & renal pelvis - Urothelial neoplasms-noninvasive - Noninvasive papillary urothelial carcinoma low grade. Often associated with positive margins (relative to other urothelial carcinomavariants); spreads along fascial planes. 1. Overlying surface may show usual urothelial carcinoma in situ, papillary carcinoma or micropapillary carcinoma Features: 1. ; Eble, JN. Urothelial cells with dark (jet black) chromatin. Chen, JC. 3. 24, No. Compared with tubular cells that also often have jet black chromatin, the nuclei of high‐grade urothelial carcinoma cells are larger and more irregular in outline, often have nuclear “points,” and often have a sickle or half‐moon shape (A and B: single image; C: composite image; Papanicolaou stain, × 1000). Grade 3 tumor resembles papilloma at low power but nuclear anaplasia is apparent at high power, Congratulations to The Scott Gwinnell Jazz Orchestra, winner of our April Pandemic Music Relief Award. ; Cheng, L. (Jul 2001). ; Koch, MO. ; Arif, T.; Geyer, S.; Zynger, DL. The direct precursor is … Comment: No urothelial carcinoma component is identified. Urothelial neoplasms with squamous morphology raise the differential diagnosis between pure primary squamous cell carcinoma, urothelial carcinoma with squamous differentiation and secondary involvement by squamous cell carcinoma, for example, from uterine cervix. Urothelial carcinomas of the renal pelvis are relatively rare tumors, and large series that include clinicopathologic and outcome data are few. chondrosarcomatous differentiation, osteosarcomatous differentiation. 2. Cytokeratins belong to the family of intermediate filaments. 6 UROTHELIAL CARCINOMAS OF THE UPPER URINARY TRACT - UPDATE MARCH 2016 Figure 3.1: Selection of patients with UTUC for hereditary screening during the first medical interview HNPCC = hereditary non-polyposis colorectal carcinoma. This website is intended for pathologists and laboratory personnel but not for patients. In a large series, PSA positivity is reported in 1.4% bladder UCC. Ta Sarcomatoid variant of urothelial carcinoma (SVUC) of the renal pelvis is a rare entity. Click, Noninvasive papillary urothelial carcinoma high grade, 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). May be useful for separation from high grade prostate carcinoma local spread 1.2. Urothelial carcinoma: Pathologic prognostic factors Stage •Most important Grade •Important only in non-muscle invasive (Ta/T1) tumours •esp. Urothelial carcinoma Benign urothelium Use of feature Utility Nuclear hyperchromasia Present Absent r/i & r/o UC Strong Nuclear-to-cytoplasmic (NC) ratio ~1:1.2 ~1:2 r/i & r/o UC; 1:>=2 suggests benign Strong Nuclear membrane D. Tumor invades lymphatic spaces. Visual survey of surgical pathology with 11065 high-quality images of benign and malignant neoplasms & related entities. EU panel backs label update for pembrolizumab in urothelial carcinoma March 30, 2021 The panel recommended adding data from the phase 3 KEYNOTE-361 trial to the label for pembrolizumab for its indication for patients with advanced or metastatic urothelial carcinoma. Invasive urothelial carcinoma with numerous lumens of variable size without glandular differentiation Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases. GATA3 immunohistochemistry in urothelial carcinoma of the upper urinary tract as a urothelial marker and a prognosticator Hum Pathol. P.2047. Gordetsky J, Epstein JI (July 2014). Although most of us are familiar with the features, behavior and treatment of the “usual” type urothelial (so-called transitional cell)carcinoma, what do we do when the pathology report comes back with an unexpected and unusual diagnosis? Anal and cervical SCC … Although technically in situ, non-invasive papillary urothelial neoplasms are staged as pTa and are not referred to as carcinoma in situ ; Liu, HS. January 2017, Vol. Urothelial dysplasia and carcinoma in situ (CIS) are related to recurrence and progression of urothelial carcinoma. The morphology of urothelial carcinomas, particularly when poorly differentiated or in metastatic sites, is not distinctive and overlaps significantly with other poorly differentiated nonurothelial carcinomas. WebPathology is a free educational resource with 11065 high quality pathology images of benign and malignant neoplasms and related entities. D'Souza, AM. "Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall". Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma. ; Daneshmand, S. (Jan 2014). E. Urothelial carcinoma in situ is present. Grade G1/2 subgroups contain relatively low-grade (LG) G2 urothelial carcinomas, which thereby. Objective: -To examine immunohistochemical markers in the context of sarcomatoid UCa, including those associated with epithelial-to-mesenchymal transition. Visual survey of surgical pathology with 11009 high-quality images of benign and malignant neoplasms & related entities. Noninvasive papillary urothelial carcinoma low grade : Complex papillary structures with branching and fusion Usually increased thickness of urothelium with architectural and cytologic atypia Papillary carcinoma without increased thickness shows marked cytologic and architectural abnormality Several types of cytokeratins have been described in normal as well as neoplastic urothelium. Women often have worse outcomes as they present with more advanced tumours. Useful features - present in invasion:[3]. Invasive urothelial carcinoma with numerous lumens of variable size without glandular differentiation Note ... Eble JN, Sauter G, Epstein JI, Sesterhenn IA eds. These lesions lack papillae and are typical flat. The term Urothelial is preferred over Transitional as is is more specific and includes neoplasms with non-transitional differentiation arising in urothelium High grade and severe dysplasia as well as some moderate dysplasia are included in carcinoma in situ [Epub ahead of print] 1 Grading of TCC Murali Varma Cardiff, UK wptmv@cf.ac.uk Sarajevo Nov 2013 Urothelial carcinoma: Pathologic prognostic factors Stage •Most important Grade •Important only in non-muscle invasive (Ta/T1) tumours •esp. Urothelial dysplasia and carcinoma in situ (CIS) are related to recurrence and progression of urothelial carcinoma. This article concerns itself with transitional cell carcinomas of the renal pelvis specifically. Ureteritis cystica. ; Skinner, EC. ; Nichols, PW. The presence/absence of muscle should be commented on in biopsy specimens. standard. Inverted Urothelial Neoplasms Focused Inverted Urothelial Neoplasms with stained slides of pathology. Urothelial carcinoma, also urothelial cell carcinoma, is a malignancy that arises from the urothelium. In half the cases the staining is weak and in the other half it is strong. Urothelial Carcinoma Lesion in Current Case NYD *Nested variant urothelial carcinoma – CK7, 34 βE12, p63, GATA3 *Prosta c adenocarcinoma – PSA, PSAP, AR *Nephrogenic adenoma/metaplasia – … Topic Completed: 1 December 2014. B. Tumor partly fills right ureteral orifice. 2012 May 17. ; Chow, NH. Approximately 25% of muscle invasive urothelial carcinoma on biopsy is a lower stage in the cystectomy specimen. Visual survey of surgical pathology with 11065 high-quality images of benign and malignant neoplasms & related entities. ; Tsai, HW. Invasive urothelial carcinoma is graded with the same criteria as papillary carcinomas; Invasion by low grade carcinomas is rare but can occur (Toll 2012) Staging. C. Tumor cells sometimes form Indian files (black arrows), appear to have nuclei that mold (red arrows), and have granular chromatin (cyan arrows), raising possibility of neuroendocrine carcinoma. Of the three markers, only GATA3 is useful for separation from squamous carcinoma 1.2.1. A. At low power, necrosis is seen, luminal, with viable invasive tumor elsewhere. Context: -Sarcomatoid urothelial carcinoma (UCa) is a rare but aggressive variant of bladder cancer that can show diagnostic challenges even using ancillary techniques. Most cases positive for p63, high molecular weight keratin and GATA3 1.1. Polyomavirus can infect urothelial carcinoma and change the morphology of these malignant cells, as is shown in this paper. . "Retrospective analysis of survival in muscle-invasive bladder cancer: impact of pT classification, node status, lymphovascular invasion, and neoadjuvant chemotherapy.". Approximately have 10% of heterologous elements, e.g. 2013;31(8):1650–5. high-grade papillary urothelial carcinoma, Pseudocarcinomatous urothelial hyperplasia, High-grade papillary urothelial carcinoma, urothelial carcinoma-like prostatic carcinoma, Muscularis propria invasion in the urinary bladder, Squamous_cell_carcinoma_of_the_lung#Lung_SCC_versus_metastatic_bladder_urothelial_carcinoma, Muscularis_propria_invasion_in_the_urinary_bladder#IHC, UCC with sarcomatoid differentiation (upmc.edu), Lymphoepithelioma-like carcinoma of the urinary bladder, "Nested variant of urothelial carcinoma of the urinary bladder. Variant (divergent) histologic differentiation in urothelial carcinoma is under-recognized in community practice: Impact of mandatory central pathology review at a large referral hospital. ; Schuckman, AK. GATA3 +ve, CK20 +ve, p63 +ve, CK5/6, HMWCK (e.g. Others. ; Dorff, TB. They are expressed in a highly specific manner in epithelial cells where they play a crucial role in the integrity and mechanical stability of the cells. "P63 immunoreactivity distinguishes upper urinary tract transitional-cell carcinoma and renal-cell carcinoma even in poorly differentiated tumors.". Mitra, AP. 2003 Dec;16(12):1289-98 Volmar KE, Chan TY, De Marzo AM, Epstein JI. Aggresive. Minor changes: 30 March 2020 ↑ Grignon, David J 22: Visual survey of surgical pathology with 11065 high-quality images of benign and malignant neoplasms & related entities. ; Ho, CL. In addition, the WHO 1973 system has led some pathol- ogists to ambiguously grade tumours that fall between grades 1 and 2 as G1/2, and tumours that fall between grades 2 and 3 as G2/3. Invasive urothelial carcinoma is graded with the same criteria as papillary carcinomas Invasion by low grade carcinomas is rare but can occur (Toll 2012) Staging Although technically in situ, non-invasive papillary urothelial Urothelial carcinoma is abbreviated UC and urothelial cell carcinoma is abbreviated UCC. "Cytokeratin 7 and cytokeratin 20 in primary urinary bladder carcinoma and matched lymph node metastasis.". Am J Surg Pathol 2011; 35:1337. 1 Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 2011 Jul;39(7):531-5. doi: 10.1002/dc.21490. surgpathcriteria.stanford.edu/...urothelial-carcinoma/printable.html Visual survey of surgical pathology with 11065 high-quality images of benign and malignant neoplasms & related entities. To determine whether Brenner tumors and transitional cell carcinomas (TCCs) of the ovary are urothelial in type, the immunoprofiles of 14 Brenner tumors, including three malignant examples, and eight ovarian TCCs were compared with those of Walthard nests, urothelium, 12 urinary bladder TCCs and 17 … Visual survey of surgical pathology with 11065 high-quality images of benign and malignant neoplasms & related entities. Approximately have 10% of heterologous elements, [1] e.g. Urothelial carcinoma is abbreviated UC and urothelial cell carcinoma is abbreviated UCC. Upper tract urothelial carcinoma often present after a bladder cancer. Variant (divergent) histologic differentiation in urothelial carcinoma is under-recognized in community practice: impact of mandatory central pathology review at a large referral hospital. CK34betaE12) +ve. Urol Oncol. By Bahram Robert Oliai, M.D. Material and methods: An eighty year old Hispanic male was referred to the urology clinic for diagnosis and treatment. Prognosis is better for pTa (noninvasive) than pT1 (invasive into lamina propria, Transurethral resection and fulguration of visible tumor, Radical cystectomy, variable chemotherapy or radiation therapy, In men, radical therapy includes cystoprostatectomy and excision of seminar vesicles, In women, radical therapy includes excision of uterus, tubes, ovaries, anterior vagina, urethra, Ileal conduit is fashioned into a new bladder with reimplantation of ureters, Sessile or cauliflower-like with necrosis and ulceration, Predominantly disorderly appearance (loss of linear orientation perpendicular to basement membrane) at low power with prominent architectural and cytologic abnormalities, Often have complex papillary architecture showing anastomosis of papillae and confluence on low-power examination, Often cellular dyscohesion and denudation, More nuclear pleomorphism / anaplasia than low grade, clumped chromatin, irregular nuclear contour, prominent nucleoli, irregularly clustered cells with crowding and overlapping, disorganized epithelium, mitotic figures at all levels including surface, which may be atypical, Some tumors may show more monomorphic nuclei; nuclear rounding is common, Highest grade tumors may not appear urothelial, may have indistinct cell borders, Associated with carcinoma in situ or dysplasia in adjacent nonpapillary urothelium, Grade according to highest grade within a tumor, ignoring miniscule areas of higher grade tumor, High-grade designation is clinical threshold for adjuvant intravesical therapy, Beta hCG in 1/3 of urothelial carcinomas, particularly high grade or high stage tumors (, Overexpression of p53, HER2, EGFR and loss of p21Waf1 or P27kip1, Deletion of 2q, 5q, 10q, 18q, and gain at 5p, 20q. Context: Relatively little is known about estrogen receptor (ER) expression in papillary urothelial carcinoma (PUC) of the bladder. PMID 24246859 . . Leroy X, Leteurtre E, De La Taille A, et al. Urol Oncol. This article deals with flat invasive urothelial carcinoma. https://librepathology.org/wiki/Micropapillary_urothelial_carcinoma Histology for Pathologists. By ProPath Staff On many occasions, the distinction of prostate adenocarcinoma from urothelial carcinoma (transitional cell carcinoma) of bladder origin is readily made on standard H&E examination. The average duration of exposure The average duration of exposure needed to develop UTUC is ~7 years, with a latency of ~20 years following termination of exposure. Urothelial carcinoma in situ - strong association with CIS in the urinary bladder. A 70‐year‐old man, who had undergone left radical nephrectomy for renal cell carcinoma in August 2003 and partial lobectomy for pulmonary metastasis in May 2005, complained of hematuria in June 2005. Mod Pathol. Retraction artefact around the tumour cell nests. //www.ncbi.nlm.nih.gov/pmc/articles/PMC3282447/. Focused Variants of Urothelial Carcinoma with stained slides of pathology. For metastatic urothelial carcinoma: Tecentriq 1,200 mg IV over 60 min for 3 weeks For treatment of nonsquamous non small cell lung cancer: Tecentriq 1,200 mg IV over 60 minutes, followed by bevacizumab, paclitaxel and chondrosarcomatous differentiation, osteosarcomatous differentiation. ; Younger, C.; Sanchez, K.; Bostwick, DG. 2003 Dec;16(12):1289-98 Mod Pathol. Inverted Urothelial Neoplasms Focused Inverted Urothelial Neoplasms with stained slides of pathology. Webpathology.com: A Collection of Surgical Pathology Images Urothelial Carcinoma-in-situ Bochner, BH. Urol Oncol. Langner, C.; Ratschek, M.; Tsybrovskyy, O.; Schips, L.; Zigeuner, R. (Aug 2003). We reviewed 130 consecutive nephroureterectomies performed for urothelial carcinoma of the renal pelvis at our … See urine cytology for the cytopathology. Metastatic UCC versus primary lung squamous cell carcinoma: UCC with some suspicion for muscularis propria invasion. ; Skinner, DG. Sternberg, SE. Urothelial dysplasia leads to urothelial carcinoma in most cases and early detection of it could provide better therapeutic effects [68]. Distinguishing CIS and dysplasia from reactive atypia is often difficult on the basis of histological features alone. T1a - superficial or in muscularis mucosae. Jiang, J.; Ulbright, TM. PMID: 17721199 DOI: 10.1097/PAS.0b013e3180588283 Comment: No urothelial carcinoma component is identified. Greater understanding of this feature of PUCs could aid with the treatment and identification of the origin of metastases, particularly with relation to the morphologically similar entity of ovarian transitional cell carcinoma (TCC). Clinically, it may not be possible to differentiate renal pelvis urothelial carcinoma and. Lung SCC negative 1.2.2. Polyomavirus infection and urothelial carcinoma Diagn Cytopathol. urothelial carcinoma of the bladder [Hoang L et al. ; Quinn, DI. (Oct 2012). Thus, it is papillary urothelial neoplasm of low malignant potential pathology outlines to develop efficient and safe serum-free culture media and eventually serum-independent cell … The differential diagnosis includes (1) primary adenocarcinoma of the bladder, (2) adenocarcinoma from another organ (direct extension or metastasis), (3) urothelial carcinoma with glandular differentiation without sampled urothelial carcinoma, and (4) urachal adenocarcinoma. ; Tzai, TS. Abstract The case is reported of urothelial carcinoma (clear cell variant) that was diagnosed with useful immunohistochemistry stain. Adenocarcinoma of the urinary bladder arising from the urothelial lining is an uncommon malignant neoplasm, accounting for 0.5% to 2.0% of all malignant vesical tumors.1 The histologic variants show a predominant colonic (enteric) type glandular morphology with varied histologic patterns. 2012 May 17. To the best of our knowledge, around 25 cases of this neoplasm have been reported in the literature to date, most of which were of high stage. Dotan, ZA. Adipose tissue may be seen in the lamina propria; tumour adjacent to adipose tissue on a biopsy does. IHC : CK20 +ve (full thickness), Ki-67 high, p53 +ve, CD44 -ve, CK7 +ve The direct precursor is dealt with in urothelial carcinoma in situ. Microcystic transitional cell carcinoma: a report of 2 cases arising in the renal pelvis. ; Yang, WH. https://librepathology.org/wiki/High-grade_papillary_urothelial_carcinoma Urinary bladder papilloma pathology, Search Articles Papilloma urothelial pathology outlines - fotobiennale. ; Pohar, KS. High grade urothelial carcinoma in a 43 year old man. ", 10.1043/0003-9985(2001)1250921:CACIPU2.0.CO;2, http://www.nature.com/modpathol/journal/v22/n2s/full/modpathol200926a.html, https://librepathology.org/w/index.php?title=Urothelial_carcinoma&oldid=46876, Attribution-NonCommercial-ShareAlike 4.0 International, not used for diagnosis; typically: 9p deletions, 17p deletions. (Mar 1995). Sarcoma cancer abdominal Uterine cancer on mri papilloma vs squamous cell carcinoma, papilloma removal nyc paraziti peste crud. Uncommon. Pathology Report Urothelial Carcinoma With Squamous Differentiation Is Associated With High Tumor Stage and Pelvic Lymph-Node Metastasis Yunguang Liu, MD, PhD, Marilyn M. Bui, MD, and Bo Xu, MD, PhD. Cytokeratin 20 (CK20), p53, and Ki-67 are related either to neopla … "Invasive low-grade papillary urothelial carcinoma: a clinicopathologic analysis of 41 cases.". (Dec 2007). "Effect of gender on outcomes following radical cystectomy for urothelial carcinoma of the bladder: a critical analysis of 1,994 patients.". [Epub ahead of print] Epub 2010 Oct 1. Inverted urothelial papilloma: may mimic endophytic growth in high-grade urothelial carcinoma; cytologically bland Low grade papillary urothelial carcinoma: nuclear and architectural features are less atypical; mitoses are variable but not on surface; cellular dyscohesion less common; prominent umbrella cells are occasionally seen ; Cheng, HL.. "Immunohistochemical detection of prostate-specific antigen expression in primary urothelial carcinoma of the urinary bladder.". The inferior vena cava tumour thrombus, which is a hallmark of renal cell carcinoma (RCC), may rarely be found in urothelial carcinoma of renal pelvis. ; Kavanagh, K.; Yossepowitch, O.; Kaag, M.; Olgac, S.; Donat, M.; Herr, HW. However, dysplasia has not been clinically detectable. "Positive surgical margins in soft tissue following radical cystectomy for bladder cancer and cancer specific survival.". The submitted voided urine sample was concentrated, processed, and a SurePath preparation was made. It develops within a type of cell in the inner lining of the bladder, ureters, and lower kidneys. 1 Cancer Control 79 urethral resection of a bladder tumor. Tumor cells are diffusely positive for CK7, focally positive for CDX2, and diffusely positive for P40, with no positivity for chromogranin or synaptophysin. F,G,H.